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Fernando W, Somaratne G, Goozee KG, Williams S, Singh H, Martins RN. Diabetes And Alzheimer’s Disease: Can Tea Phytochemicals Play A Role In Prevention? J Alzheimers Dis. 2017; May 30. Doi:10.3233/JAD161200.

Fernando W, Somaratne G, Goozee KG, Williams S, Singh H, Martins RN. Diabetes and Alzheimer’s Disease: Can Tea Phytochemicals Play a Role in Prevention? J Alzheimers Dis. 2017; May 30. Doi:10.3233/JAD161200.

Tea has been shown to have potent health promoting benefits including antioxidant, anti-microbial, antitumor, anti-diabetic and anti-inflammatory properties which can serve to reduce the risk factors associated with Alzheimer’s disease and dementia.

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Dietz C And Dekker M., Effect Of Green Tea Phytochemicals On Mood And Cognition. Curr Pharm Des. 2017.;Vol 23. Doi:10.2174/1381612823666170105151800.

Dietz C and Dekker M., Effect of green tea phytochemicals on mood and cognition. Curr Pharm Des. 2017.;Vol 23. Doi:10.2174/1381612823666170105151800.

This article is a review of 49 human intervention studies investigating the effects on phytochemicals found in green tea including L-theanine, EGCG and caffeine on various aspects of mood (relaxation and alertness) and cognition (sustained attention and memory).

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Boespflug EL Et Al., Fish Oil Supplementation Increases Event-related Posterior Cingulate Activation In Older Adults With Subjective Memory Impairment. J Nutr Health Aging. 2016;20(2):161-9.

Boespflug EL et al., Fish oil supplementation increases event-related posterior cingulate activation in older adults with subjective memory impairment. J Nutr Health Aging. 2016;20(2):161-9.

This study suggests dietary fish oil supplementation can support cognitive function in healthy older adults with subjective memory impairment.

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Cox KH Et Al., Investigation Of The Effects Of Solid Lipid Curcumin On Cognition And Mood In A Healthy Older Population. J Of Psychopharmacology 2015;29(5):642-51.

Cox KH et al., Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. J of Psychopharmacology 2015;29(5):642-51.

Improved performance on sustained attention (digit vigilance task) and working memory (serial three subtraction task) was enhanced upon acute treatment (1 and 3 hr after single dose) and working memory and mood (i.e. general fatigue, state calmness, fatigue induced by stress) were significantly improved following chronic treatment (4 weeks).

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Yurko-Mauro K Et Al., Docosahexaenoic Acid And Adult Memory: A Systematic Review And Metaanalysis. PLoS One. 2015;10(3):e0120391.

Yurko-Mauro K et al., Docosahexaenoic acid and adult memory: a systematic review and metaanalysis. PLoS One. 2015;10(3):e0120391.

This systematic literature review finds that 1g/day of DHA/EPA improved episodic memory. Furthermore, observational studies support and association between intake of DHA/EPA and memory function in older adults.

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Bauer I Et Al., Omega-3 Supplementation Improves Cognition And Modifies Brain Activation In Young Adults. Hum Psychopharmacol. 2014;29(2)133-44.

Bauer I et al., Omega-3 supplementation improves cognition and modifies brain activation in young adults. Hum Psychopharmacol. 2014;29(2)133-44.

In a double blind, crossover design, with a 30 day washout period between the two supplements, investigators found that with EPA supplementation the subjects had a better cognitive performance than prior to supplementation. EPA supplementation resulted in a decrease in function in the left anterior cingulate cortex and an increase in activation in the right precentralgyrus during the Stroop task.

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Latimer CS Et Al., Vitamin D Prevents Cognitive Decline And Enhances Hippocampal Synaptic Functioning In Aging Rats. PNAS. 2014;111(41):E4359-E4366.

Latimer CS et al., Vitamin D prevents cognitive decline and enhances hippocampal synaptic functioning in aging rats. PNAS. 2014;111(41):E4359-E4366.

This study investigated whether increasing dietary vitamin D to optimal levels for a 6 month time frame could enhance cognitive function in aging rats. The research demonstrates that rats on high vitamin D significantly outperformed low and medium groups on challenging tasks involving memory. Synaptic transmission was also enhanced in the high vitamin D group.

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Pottala, JV Et Al., Higher RBC EPA+DHA Corresponds With Larger Brain And Total Hippocampal Volumes WHIMS-MRI Study. Neurology. 2014; 82(5):435-442.

Pottala, JV et al., Higher RBC EPA+DHA corresponds with larger brain and total hippocampal volumes WHIMS-MRI study. Neurology. 2014; 82(5):435-442.

Red blood cell EPA, DHA and MRI brain volumes were assessed in 1,111 postmeonpausal women from the Women’s Health Initiative Memory Study. A higher omega-3 index was correlated with larger total normal brain volume and hippocampal volume (area of working memory) in women measured 8 years later.

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Dietz C And Dekker M., Effect Of Green Tea Phytochemicals On Mood And Cognition. Curr Pharm Des. 2017.;Vol 23. Doi:10.2174/1381612823666170105151800.

Dietz C and Dekker M., Effect of green tea phytochemicals on mood and cognition. Curr Pharm Des. 2017.;Vol 23. Doi:10.2174/1381612823666170105151800.

This article is a review of 49 human intervention studies investigating the effects on phytochemicals found in green tea including L-theanine, EGCG and caffeine on various aspects of mood (relaxation and alertness) and cognition (sustained attention and memory).

Read More
Cox KH Et Al., Investigation Of The Effects Of Solid Lipid Curcumin On Cognition And Mood In A Healthy Older Population. J Of Psychopharmacology 2015;29(5):642-51.

Cox KH et al., Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. J of Psychopharmacology 2015;29(5):642-51.

This randomized, double-blind, placebo-controlled trial measured the effects of solid lipid curcumin formulation (400 mg Longvida® Optimized Curcumin which is the equivalent of 80 mg curcumin) on cognitive function, mood and blood biomarkers in 60 healthy adults aged 60-85.

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Currais A Et Al., Fisetin Reduces The Impact Of Again On Behavior And Physiology In The Rapidly Aging SAMP8 Mouse. J Gerontol A Biol Sci Med Sci. 2017; June 2 Doi:10.1093/Gerona/glx104.

Currais A et al., Fisetin reduces the impact of again on behavior and physiology in the rapidly aging SAMP8 mouse. J Gerontol A Biol Sci Med Sci. 2017; June 2 doi:10.1093/Gerona/glx104.

Fisetin was found to be effective against brain aging and cognitive dysfunction in rapidly aging SAMP8 mice, a mouse model for sporadic Alzheimer’s disease and dementia.

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Annweiler C, Vitamin D In Dementia Prevention. Ann NY Acad Sci. 2016;1367(1)57-63.

Annweiler C, Vitamin D in dementia prevention. Ann NY Acad Sci. 2016;1367(1)57-63.

The actions of the neurosteroid vitamin D as it applies to neurological issues include its antioxidant and antiinflammatory effects as well as its clearance of amyloid-B peptide, which is associated with Alzheimer’s disease (AD). Lower concentrations of vitamin D have been associated with cognitive decline and executive dysfunction and have been associated with increased AD risk.

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Ma QL Et Al., Curcumin Suppresses Soluble Tau Dimers And Corrects Molecular Chaperone, Synaptic And Behavioral Deficits In Aged Human Tau Transgenic Mice, JBC 2013; 288(6): 4056-4065.

Ma QL et al., Curcumin suppresses soluble tau dimers and corrects molecular chaperone, synaptic and behavioral deficits in aged human tau transgenic mice, JBC 2013; 288(6): 4056-4065.

Aged human Tau transgenic mice with neurofibrillary tangles and tau accumulation, common pathological hallmarks in degenerative disease, were fed diets with curcumin (Longvida-550 ppm) added to the chow. The results demonstrate that curcumin fed human Tau transgenic mice but not control mice had a reduction in soluble Tau dimers through the upregulation of heat shock proteins.

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Tan ZS, Harris WS, Beiser AS, Et Al. Red Blood Cell Omega-3 Fatty Acid Levels And Markers Of Accelerated Brain Aging. Neurology. 2012;78(9):658-664.

Tan ZS, Harris WS, Beiser AS, et al. Red blood cell omega-3 fatty acid levels and markers of accelerated brain aging. Neurology. 2012;78(9):658-664.

This study investigated the red blood cell count of omega-3 fatty acid levels (EPA and DHA) in dementia free Framingham Study participants (n=1,575; 854 women, age 67 ± 9 yr) to performance on cognitive tests and brain volumes as measured by MRI. Lower red blood cell DHA levels were associated with lower brain volumes, greater white matter hyperintensity volume.

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Banerjee A Et Al., Vitamin D And Alzheimer’s Disease: Neurocognition To Therapeutics. Int J Alzheimers Dis. 2015;2015:192747.

Banerjee A et al., Vitamin D and Alzheimer’s disease: Neurocognition to Therapeutics. Int J Alzheimers Dis. 2015;2015:192747.

This review discusses the role of vitamin D in neurocognition and optimal brain health and gives evidence for this high rate of hypovitaminosis D among the aged and AD population.

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Fernando W, Somaratne G, Goozee KG, Williams S, Singh H, Martins RN. Diabetes And Alzheimer’s Disease: Can Tea Phytochemicals Play A Role In Prevention? J Alzheimers Dis. 2017; May 30. Doi:10.3233/JAD161200.

Fernando W, Somaratne G, Goozee KG, Williams S, Singh H, Martins RN. Diabetes and Alzheimer’s Disease: Can Tea Phytochemicals Play a Role in Prevention? J Alzheimers Dis. 2017; May 30. Doi:10.3233/JAD161200.

Tea has been shown to have potent health promoting benefits including antioxidant, anti-microbial, antitumor, anti-diabetic and anti-inflammatory properties which can serve to reduce the risk factors associated with Alzheimer’s disease and dementia.

Read More
Bastianetto S, Yao ZX, Papadopoulos V, Quirion R. Neuroprotective Effects Of Green And Black Teas And Their Catechin Gallate Esters Against Beta-amyloid-induced Toxicity. Eur J Neurosci. 2006;23(1):55-64.

Bastianetto S, Yao ZX, Papadopoulos V, Quirion R. Neuroprotective effects of green and black teas and their catechin gallate esters against beta-amyloid-induced toxicity. Eur J Neurosci. 2006;23(1):55-64.

Catechins are antioxidants found in green tea that may positive influence pathology and reduce the risk factors associated with Alzheimer’s disease.

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Arab H Et Al., The Effect Of Green Tea Consumption On Oxidative Stress Markers And Cognitive Function In Patients With Alzheimer’s Disease: A Prospective Intervention Study. Caspian J Intern Med. 2016; 7(3):188- 194.

Arab H et al., The effect of green tea consumption on oxidative stress markers and cognitive function in patients with Alzheimer’s disease: A prospective intervention study. Caspian J Intern Med. 2016; 7(3):188- 194.

The findings from this prospective intervention study in 30 patients with severe Alzheimer’s disease report that two months of green tea supplementation (2g/day) demonstrate that the total antioxidant capacity of plasma increased significantly along with improved scores on the Mini-Mental State Examination, suggesting beneficial effects on cognitive function.

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Currais A Et Al., Fisetin Reduces The Impact Of Again On Behavior And Physiology In The Rapidly Aging SAMP8 Mouse. J Gerontol A Biol Sci Med Sci. 2017; June 2 Doi:10.1093/Gerona/glx104.

Currais A et al., Fisetin reduces the impact of again on behavior and physiology in the rapidly aging SAMP8 mouse. J Gerontol A Biol Sci Med Sci. 2017; June 2 doi:10.1093/Gerona/glx104.

Fisetin was found to be effective against brain aging and cognitive dysfunction in rapidly aging SAMP8 mice, a mouse model for sporadic Alzheimer’s disease and dementia.

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Currais A Et Al., Modulation Of P25 And Inflammatory Pathways By Fisetin Maintains Cognitive Function In Alzheimer’s Disease Transgenic Mice. Aging Cell, 2013; 13(2):379-390.

Currais A et al., Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer’s disease transgenic mice. Aging Cell, 2013; 13(2):379-390.

In a study performed at the Salk Institute on transgenic mice that develop Alzheimer’s disease demonstrated that supplementing the diet with fisetin from 3-12 months prevents the development of learning and memory deficits. Furthermore, fisetin reduces levels of proteins (Cdk5 and p25) that lead to neuroinflammation and neurodegeneration.

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Ahmad A Et Al., Neuroprotective Effect Of Fisetin Against Amyloid-beta-induced Cognitive Dysfunction, Neuroinflammation, And Neurodegeneration In Adult Mice. Mol Neurobiol. 2017; 54(3): 2269-2285.

Ahmad A et al., Neuroprotective effect of fisetin against amyloid-beta-induced cognitive dysfunction, neuroinflammation, and neurodegeneration in adult mice. Mol Neurobiol. 2017; 54(3): 2269-2285.

This study investigated the neuroprotective effect of fisetin and demonstrated a decrease in the accumulation of Aβ expression and hyperphosphorylation of tau (pathologic hallmarks of Alzheimer’s disease), a reversal in synaptic dysfunction, improvements in memory and prevention of inflammation in the Aβ1-42 mouse model of Alzheimer’s disease.

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Sun GY Et Al., Docosahexaenoic Acid (DHA): An Essential Nutrient And A Neutraceutical For Brain Health And Diseases. Prostaglandins Leukot Essent Fatty Acids. 2017; Mar 10. Doi:10.1016/plefa.2017

Sun GY et al., Docosahexaenoic acid (DHA): An essential nutrient and a neutraceutical for brain health and diseases. Prostaglandins Leukot Essent Fatty Acids. 2017; Mar 10. Doi:10.1016/plefa.2017

DHA is enriched in phospholipids in the brain and retina and is known to participate in many functional roles in brain health and disease. This review describe the studies on DHA and the molecular mechanisms (antioxidant pathways, signaling pathways, modulation of Brain Derived Neurotropic Factor) underlying its role in various neuropsychiatric and neurodegenerative disorders.

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Freund-Levi Y Et Al., Transfer Of Omega-3 Fatty Acids Across The Blood-brain Barrier After Dietary Supplementation With A Docosahexaenoic Acid-rich Omega-3 Fatty Acid Preparation In Patients With Alzheimer’s Disease: The OmegAD Study. J Intern Med. 2014;275(4):428-36.

Freund-Levi Y et al., Transfer of omega-3 fatty acids across the blood-brain barrier after dietary supplementation with a docosahexaenoic acid-rich omega-3 fatty acid preparation in patients with Alzheimer’s disease: the OmegAD study. J Intern Med. 2014;275(4):428-36.

Thirty three patients who were participants in a double-blind, randomized, placebo-controlled OmegaAD study in which 204 patients with mild Alzheimer’s disease received 2.3g of essential fatty acids (high in DHA) or placebo for 6 months. At 6 months, the group receiving essential fatty acids displayed significant increases in EPA and DHA in the cerebrospinal fluid.

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Cole Et Al., Prevention Of Alzheimer’s Disease: Omega-3 Fatty Acid And Phenolic Anti-oxidant Interventions. Neurobiol Aging. 2005; 1:133-6.

Cole et al., Prevention of Alzheimer’s disease: Omega-3 fatty acid and phenolic anti-oxidant interventions. Neurobiol Aging. 2005; 1:133-6.

The dietary omega 3 fatty acid, DHA, limited amyloid, oxidative stress induced damage and synaptic and cognitive deficits in an APP transgenic mouse model of AD.

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Latimer CS Et Al., Vitamin D Prevents Cognitive Decline And Enhances Hippocampal Synaptic Functioning In Aging Rats. PNAS. 2014;111(41):E4359-E4366.

Latimer CS et al., Vitamin D prevents cognitive decline and enhances hippocampal synaptic functioning in aging rats. PNAS. 2014;111(41):E4359-E4366.

This study investigated whether increasing dietary vitamin D to optimal levels for a 6 month time frame could enhance cognitive function in aging rats. The research demonstrates that rats on high vitamin D significantly outperformed low and medium groups on challenging tasks involving memory. Synaptic transmission was also enhanced in the high vitamin D group.

Read More
Groves Et Al., Vitamin D As A Neurosteroid Affecting The Developing And Adult Brain. Annual Review Of Nutrition. 2014; 34:117-141.

Groves et al., Vitamin D as a neurosteroid affecting the developing and adult brain. Annual review of nutrition. 2014; 34:117-141.

This is a review on the important roles of vitamin D in terms of its neurotropic and neuroprotective functions as well as its role in brain function as it applies to health and disease.

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Annweiler C Et Al., Vitamin D And White Matter Abnormalities In Older Adults: A Cross-sectional Neuroimaging Study. Eur J Neurol. 2014; 21(12):1436-e95.

Annweiler C et al., Vitamin D and white matter abnormalities in older adults: a cross-sectional neuroimaging study. Eur J Neurol. 2014; 21(12):1436-e95.

This study investigated the association between vitamin D concentrations and white matter abnormalities (WMA) in 133 Caucasian community-dwellers with no clinical hydrocephalus (average age 71± 5.6years). Lower serum vitamin D concentrations were associated with a high grade of WMA. These findings provide a scientific basis for vitamin D supplementation in older adults.

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Zamroziewicz MK, Paul EJ, Zwilling CE, Barbey AK. Determinants Of Fluid Intelligence In Healthy Aging: Omega-3 Polyunsaturated Fatty Acid Status And Frontoparietal Cortex Structure. Nutr Neurosci. 2017;1-10.

Zamroziewicz MK, Paul EJ, Zwilling CE, Barbey AK. Determinants of fluid intelligence in healthy aging: Omega-3 polyunsaturated fatty acid status and frontoparietal cortex structure. Nutr Neurosci. 2017;1-10.

Specific omega-3 polyunsaturated fatty acids have an impact on maintaining the structural integrity of a grey matter area vulnerable to age related decline in the brains of cognitively intact older adults.

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Maher P., How Fisetin Reduces The Impact Of Age And Disease On CNS Function. Front Biosci. 2015; 1(7):58- 82.

Maher P., How fisetin reduces the impact of age and disease on CNS function. Front Biosci. 2015; 1(7):58- 82.

Fisetin has multiple biological functions in the body including antioxidant protection, anti-inflammatory activity, increasing intracellular glutathione levels and it has been shown to impact neurotropic signaling pathways. This is a review of the novel neuroprotective and cognitive-enhancing molecule fisetin.

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Tan ZS, Harris WS, Beiser AS, Et Al. Red Blood Cell Omega-3 Fatty Acid Levels And Markers Of Accelerated Brain Aging. Neurology. 2012;78(9):658-664.

Tan ZS, Harris WS, Beiser AS, et al. Red blood cell omega-3 fatty acid levels and markers of accelerated brain aging. Neurology. 2012;78(9):658-664.

This study investigated the red blood cell count of omega-3 fatty acid levels (EPA and DHA) in dementia free Framingham Study participants (n=1,575; 854 women, age 67 ± 9 yr) to performance on cognitive tests and brain volumes as measured by MRI. Lower red blood cell DHA levels were associated with lower brain volumes, greater white matter hyperintensity volume.

Read More
Sun GY Et Al., Docosahexaenoic Acid (DHA): An Essential Nutrient And A Neutraceutical For Brain Health And Diseases. Prostaglandins Leukot Essent Fatty Acids. 2017; Mar 10. Doi:10.1016/plefa.2017

Sun GY et al., Docosahexaenoic acid (DHA): An essential nutrient and a neutraceutical for brain health and diseases. Prostaglandins Leukot Essent Fatty Acids. 2017; Mar 10. Doi:10.1016/plefa.2017

DHA is enriched in phospholipids in the brain and retina and is known to participate in many functional roles in brain health and disease. This review describe the studies on DHA and the molecular mechanisms (antioxidant pathways, signaling pathways, modulation of Brain Derived Neurotropic Factor) underlying its role in various neuropsychiatric and neurodegenerative disorders.

Read More
Ma QL Et Al., Curcumin Suppresses Soluble Tau Dimers And Corrects Molecular Chaperone, Synaptic And Behavioral Deficits In Aged Human Tau Transgenic Mice, JBC 2013; 288(6): 4056-4065.

Ma QL et al., Curcumin suppresses soluble tau dimers and corrects molecular chaperone, synaptic and behavioral deficits in aged human tau transgenic mice, JBC 2013; 288(6): 4056-4065.

Aged human Tau transgenic mice with neurofibrillary tangles and tau accumulation, common pathological hallmarks in degenerative disease, were fed diets with curcumin (Longvida-550 ppm) added to the chow. The results demonstrate that curcumin fed human Tau transgenic mice but not control mice had a reduction in soluble Tau dimers through the upregulation of heat shock proteins.

Read More
DiSilvestro RA Et Al., Diverse Effects Of A Low Dose Supplement Of Lipidated Curcumin In Healthy Middle Aged People. Nutrition Journal 2012; 11:79.

DiSilvestro RA et al., Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people. Nutrition Journal 2012; 11:79.

A low dose (80mg/day) of a curcumin-lipid preparation can produce a variety of various health promoting effects within a 4 week time frame as assessed by blood and saliva samples including lowering plasma triglyceride levels, lowering of salivary amylase activity, raising of salivary radical scavenging capacities, raising of plasma catalase activities, increased plasma nitric oxide levels.

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1.	Currais A Et Al., Fisetin Reduces The Impact Of Again On Behavior And Physiology In The Rapidly Aging SAMP8 Mouse. J GerontolABiolSci Med Sci. 2017; June 2 Doi:10.1093/Gerona/glx104.

1. Currais A et al., Fisetin reduces the impact of again on behavior and physiology in the rapidly aging SAMP8 mouse. J GerontolABiolSci Med Sci. 2017; June 2 doi:10.1093/Gerona/glx104.

Fisetin is a naturally occurring flavonoid found abundantly in strawberries founds in fruits and vegetables and has been found to have multiple biological activities that are relevant to healthy central nervous system function. The literature below discusses the neuroprotective role of fisetin on brain function and its potential to protect the aging brain from degenerative disorders.

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Mice Synaptic, And Behavioral Deficits In Aged And Corrects Molecular Chaperone, Curcumin

Mice Synaptic, and Behavioral Deficits in Aged and Corrects Molecular Chaperone, Curcumin

The mechanisms underlying Tau-related synaptic and cognitive deficits and the interrelationships between Tau species, their clearance pathways, and synaptic impairments remain poorly understood. To gain insight into these mechanisms, we examined these interrelationships in aged non-mutant genomic human Tau mice, with established Tau pathology and neuron loss.

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Investigation Of The Effects Of Solid Lipid Curcumin On Cognition And Mood In A Healthy Older Population

Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population

Curcumin possesses many properties which may prevent or ameliorate pathological processes underlying age-related cognitive decline, dementia or mood disorders. These benefits in preclinical studies have not been established in humans. This randomized, double-blind, placebo-controlled trial examined the acute (1 and 3 h after a single dose), chronic (4 weeks) and acute-on-chronic.

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Safety And Pharmacokinetics Of A Solid Lipid Curcumin Particle Formulation In Osteosarcoma Patients And Healthy Volunteers

Safety and Pharmacokinetics of a Solid Lipid Curcumin Particle Formulation in Osteosarcoma Patients and Healthy Volunteers

Curcumin is the lipid-soluble antioxidant compound obtained from the rhizome of Curcuma longa Linn, also known as turmeric. Curcumin targets multiple chemotherapeutic and inflammatory pathways and has demonstrated safety and tolerability in humans, supporting its potential as a therapeutic agent; however, the clinical literature lacks conclusive evidence supporting.

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Diverse Effects Of A Low Dose Supplement Of Lipidated Curcumin In Healthy Middle Aged People

Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people

Curcumin extracts of turmeric are proposed to produce health benefits. To date, human intervention studies have focused mainly on people with existing health problems given high doses of poorly absorbed curcumin. The purpose of the current study was to check whether in healthy people, a low dose of a lipidated curcumin extract could alter wellness-related measures.

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